[4] Cruz Azul 1-2 Santos Laguna [18] 2022-02-28 01:00
Stadium: Estadio Azteca Round: 7
Referee: Cesar Arturo Ramos Palazuelos Home Manager: Juan Reynoso Away Manager: Pedro Caixinha
Head to Head
| Meksyk - Liga MX | 2021/08/01 23:00 | Santos Laguna v Cruz Azul | D | 1-1 |
| Meksyk - Liga MX | 2021/05/31 01:15 | Cruz Azul v Santos Laguna | D | 1-1 |
| Meksyk - Liga MX | 2021/05/28 02:00 | Santos Laguna v Cruz Azul | W | 0-1 |
| Meksyk - Liga MX | 2021/01/11 01:06 | Santos Laguna v Cruz Azul | L | 1-0 |
| Meksyk - Liga MX | 2020/07/26 02:00 | Cruz Azul v Santos Laguna | W | 2-0 |
| Meksyk - Liga MX | 2020/01/25 23:00 | Cruz Azul v Santos Laguna | W | 3-0 |
| Meksyk - Liga MX | 2019/11/11 00:45 | Santos Laguna v Cruz Azul | L | 3-1 |
| Meksyk - Liga MX | 2019/02/16 23:00 | Cruz Azul v Santos Laguna | L | 1-2 |
| Meksyk - Liga MX | 2018/08/26 23:00 | Santos Laguna v Cruz Azul | D | 1-1 |
| Meksyk - Liga MX | 2018/02/26 00:00 | Santos Laguna v Cruz Azul | L | 2-0 |
| Meksyk - Liga MX | 2017/09/16 22:00 | Cruz Azul v Santos Laguna | W | 2-1 |
| Puchar Meksyku | 2017/03/15 01:00 | Santos Laguna v Cruz Azul | W | 1-3 |
| Meksyk - Liga MX | 2017/02/13 00:00 | Santos Laguna v Cruz Azul | D | 2-2 |
| Meksyk - Liga MX | 2016/08/20 22:00 | Cruz Azul v Santos Laguna | W | 3-1 |
| Meksyk - Liga MX | 2016/04/16 22:00 | Cruz Azul v Santos Laguna | L | 0-1 |
| Meksyk - Liga MX | 2015/10/24 02:30 | Santos Laguna v Cruz Azul | W | 1-2 |
| Meksyk - Liga MX | 2015/01/17 23:00 | Cruz Azul v Santos Laguna | W | 1-0 |
| Meksyk - Liga MX | 2014/07/26 02:30 | Santos Laguna v Cruz Azul | D | 1-1 |