[4] Cruz Azul 1-2 Santos Laguna [18] 2022-02-28 01:00
Stadium: Estadio Azteca Round: 7
Referee: Cesar Arturo Ramos Palazuelos Home Manager: Juan Reynoso Away Manager: Pedro Caixinha
Head to Head
| Meksyk - Liga MX | 2021/08/01 23:00 | Santos Laguna v Cruz Azul | D | 1-1 |
| Meksyk - Liga MX | 2021/05/31 01:15 | Cruz Azul v Santos Laguna | D | 1-1 |
| Meksyk - Liga MX | 2021/05/28 02:00 | Santos Laguna v Cruz Azul | W | 0-1 |
| Meksyk - Liga MX | 2021/01/11 01:06 | Santos Laguna v Cruz Azul | L | 1-0 |
| Meksyk - Liga MX | 2020/07/26 02:00 | Cruz Azul v Santos Laguna | W | 2-0 |
| Meksyk - Liga MX | 2020/01/25 23:00 | Cruz Azul v Santos Laguna | W | 3-0 |
| Meksyk - Liga MX | 2019/11/11 00:45 | Santos Laguna v Cruz Azul | L | 3-1 |
| Meksyk - Liga MX | 2019/02/16 23:00 | Cruz Azul v Santos Laguna | L | 1-2 |
Home History
| Puchar Mistrzów CONCACAF | 2022/02/25 01:30 | Cruz Azul v Forge FC | W | 3-1 |
| Meksyk - Liga MX | 2022/02/21 00:00 | Toluca v Cruz Azul | W | 1-4 |
| Puchar Mistrzów CONCACAF | 2022/02/17 01:00 | Forge FC v Cruz Azul | W | 0-1 |
| Meksyk - Liga MX | 2022/02/13 01:00 | Cruz Azul v Necaxa | L | 1-2 |
| Meksyk - Liga MX | 2022/02/08 03:05 | Leon v Cruz Azul | W | 0-1 |
| Meksyk - Liga MX | 2022/01/23 03:06 | Monterrey v Cruz Azul | D | 2-2 |
| Meksyk - Liga MX | 2022/01/16 03:00 | Cruz Azul v Juarez FC | W | 1-0 |
| Meksyk - Liga MX | 2022/01/09 03:00 | Cruz Azul v Tijuana | W | 2-0 |
Away History
| Puchar Mistrzów CONCACAF | 2022/02/24 01:15 | CF Montreal v Santos Laguna | L | 3-0 |
| Meksyk - Liga MX | 2022/02/19 03:00 | Juarez FC v Santos Laguna | D | 0-0 |
| Puchar Mistrzów CONCACAF | 2022/02/16 03:00 | Santos Laguna v CF Montreal | W | 1-0 |
| Meksyk - Liga MX | 2022/02/13 03:00 | Santos Laguna v Club America | L | 2-3 |
| Meksyk - Liga MX | 2022/02/07 00:00 | Atlas v Santos Laguna | L | 2-1 |
| Europa - Towarzyskie | 2022/01/29 02:00 | Mazatlan FC v Santos Laguna | L | 2-1 |
| Meksyk - Liga MX | 2022/01/24 01:00 | Santos Laguna v Necaxa | L | 1-4 |
| Meksyk - Liga MX | 2022/01/16 18:00 | Toluca v Santos Laguna | L | 3-1 |