[4] Monterrey 1-1 Santos Laguna [5] 2021-05-16 23:00
Stadium: Estadio BBVA Bancomer Round: 3
Referee: Cesar Arturo Ramos Palazuelos Home Manager: Javier Aguirre Away Manager: Guillermo Almada
Head to Head
| Meksyk - Liga MX | 2021/05/14 02:05 | Santos Laguna v Monterrey | L | 2-1 |
| Meksyk - Liga MX | 2021/02/15 01:06 | Santos Laguna v Monterrey | L | 1-0 |
| Meksyk - Liga MX | 2020/08/09 00:06 | Monterrey v Santos Laguna | D | 2-2 |
| Puchar Meksyku | 2020/02/20 01:00 | Monterrey v Santos Laguna | W | 1-0 |
| Puchar Meksyku | 2020/02/12 01:00 | Santos Laguna v Monterrey | D | 0-0 |
| Meksyk - Liga MX | 2019/12/02 01:00 | Santos Laguna v Monterrey | D | 1-1 |
| Meksyk - Liga MX | 2019/11/29 01:06 | Monterrey v Santos Laguna | W | 5-2 |
| Meksyk - Liga MX | 2019/08/24 02:00 | Santos Laguna v Monterrey | L | 2-1 |
| Meksyk - Liga MX | 2019/04/15 01:30 | Monterrey v Santos Laguna | W | 4-0 |
| Meksyk - Liga MX | 2018/12/02 03:00 | Santos Laguna v Monterrey | W | 0-2 |
| Meksyk - Liga MX | 2018/11/29 03:06 | Monterrey v Santos Laguna | W | 1-0 |
| Meksyk - Liga MX | 2018/10/27 00:00 | Santos Laguna v Monterrey | L | 1-0 |
| Meksyk - Liga MX | 2018/03/12 00:00 | Santos Laguna v Monterrey | L | 3-2 |
| Meksyk - Liga MX | 2017/11/10 03:00 | Monterrey v Santos Laguna | D | 1-1 |
| Puchar Meksyku | 2017/11/02 01:00 | Monterrey v Santos Laguna | W | 4-1 |
| Meksyk - Liga MX | 2017/09/28 02:00 | Monterrey v Santos Laguna | D | 1-1 |
| Meksyk - Liga MX | 2017/04/13 00:30 | Santos Laguna v Monterrey | D | 2-2 |
| Meksyk - Liga MX | 2016/09/22 02:30 | Monterrey v Santos Laguna | W | 5-2 |
| Meksyk - Liga MX | 2016/02/13 03:30 | Santos Laguna v Monterrey | W | 1-2 |
| Meksyk - Liga MX | 2015/08/23 00:00 | Monterrey v Santos Laguna | D | 1-1 |
| Meksyk - Liga MX | 2015/01/24 03:30 | Santos Laguna v Monterrey | L | 4-1 |
| Puchar Meksyku | 2014/09/24 02:00 | Santos Laguna v Monterrey | L | 2-1 |
| Puchar Meksyku | 2014/09/17 02:00 | Monterrey v Santos Laguna | L | 2-3 |
| Meksyk - Liga MX | 2014/08/03 00:00 | Monterrey v Santos Laguna | D | 0-0 |