[4] Monterrey 1-1 Santos Laguna [5] 2021-05-16 23:00
Stadium: Estadio BBVA Bancomer Round: 3
Referee: Cesar Arturo Ramos Palazuelos Home Manager: Javier Aguirre Away Manager: Guillermo Almada
Head to Head
| Meksyk - Liga MX | 2021/05/14 02:05 | Santos Laguna v Monterrey | L | 2-1 |
| Meksyk - Liga MX | 2021/02/15 01:06 | Santos Laguna v Monterrey | L | 1-0 |
| Meksyk - Liga MX | 2020/08/09 00:06 | Monterrey v Santos Laguna | D | 2-2 |
| Puchar Meksyku | 2020/02/20 01:00 | Monterrey v Santos Laguna | W | 1-0 |
| Puchar Meksyku | 2020/02/12 01:00 | Santos Laguna v Monterrey | D | 0-0 |
| Meksyk - Liga MX | 2019/12/02 01:00 | Santos Laguna v Monterrey | D | 1-1 |
| Meksyk - Liga MX | 2019/11/29 01:06 | Monterrey v Santos Laguna | W | 5-2 |
| Meksyk - Liga MX | 2019/08/24 02:00 | Santos Laguna v Monterrey | L | 2-1 |
Home History
| Meksyk - Liga MX | 2021/05/14 02:05 | Santos Laguna v Monterrey | L | 2-1 |
| Puchar Mistrzów CONCACAF | 2021/05/06 00:00 | Monterrey v Columbus Crew | W | 3-0 |
| Meksyk - Liga MX | 2021/05/02 02:06 | Monterrey v Mazatlan FC | W | 1-0 |
| Puchar Mistrzów CONCACAF | 2021/04/29 00:30 | Columbus Crew v Monterrey | D | 2-2 |
| Meksyk - Liga MX | 2021/04/25 02:15 | Tigres UANL v Monterrey | L | 2-1 |
| Meksyk - Liga MX | 2021/04/22 02:10 | Monterrey v Chivas Guadalajara | L | 1-2 |
| Meksyk - Liga MX | 2021/04/19 02:06 | Monterrey v Pachuca | L | 0-1 |
| Puchar Mistrzów CONCACAF | 2021/04/16 02:00 | Monterrey v Atletico Pantoja | W | 3-1 |
Away History
| Meksyk - Liga MX | 2021/05/14 02:05 | Santos Laguna v Monterrey | W | 2-1 |
| Meksyk - Liga MX | 2021/05/09 02:15 | Santos Laguna v Queretaro | W | 5-0 |
| Meksyk - Liga MX | 2021/05/03 00:06 | Santos Laguna v Puebla | D | 0-0 |
| Meksyk - Liga MX | 2021/04/27 02:00 | Pachuca v Santos Laguna | L | 1-0 |
| Meksyk - Liga MX | 2021/04/19 00:00 | Santos Laguna v Toluca | W | 3-1 |
| Meksyk - Liga MX | 2021/04/12 00:00 | Queretaro v Santos Laguna | L | 1-0 |
| Meksyk - Liga MX | 2021/04/04 22:00 | Chivas Guadalajara v Santos Laguna | D | 1-1 |
| Meksyk - Liga MX | 2021/03/22 01:06 | Santos Laguna v Leon | L | 1-2 |