Stadium: William B. Greene Jr. Stadium Round: 1
Home Manager: George Quarles Away Manager: Drew Cronic
| NCAAF | 2022/10/15 20:00 | East Tennessee State v Mercer | W | 33-55 |
| NCAAF | 2021/11/20 18:00 | Mercer v East Tennessee State | L | 35-38 |
| NCAAF | 2021/04/10 22:00 | East Tennessee State v Mercer | W | 13-21 |
| NCAAF | 2019/11/16 18:00 | Mercer v East Tennessee State | L | 33-38 |
| NCAAF FCS | 2018/11/03 19:00 | East Tennessee State v Mercer | L | 21-18 |
| NCAAF | 2017/09/23 19:30 | East Tennessee State v Mercer | L | 26-23 |
| NCAAF | 2023/09/30 20:00 | VMI v Mercer | W | 3-38 |
| NCAAF | 2023/09/23 17:00 | Mercer v Furman | L | 14-38 |
| NCAAF | 2023/09/09 23:00 | Morehead State v Mercer | W | 22-48 |
| NCAAF | 2023/09/02 18:00 | Mercer v Mississippi | L | 7-73 |
| NCAAF | 2023/08/26 19:30 | North Alabama v Mercer | W | 7-17 |
| NCAAF | 2022/11/19 18:00 | Mercer v Samford | L | 44-50 |
| NCAAF | 2022/11/12 20:00 | Furman v Mercer | L | 23-13 |
| NCAAF | 2022/10/29 17:30 | Mercer v VMI | W | 55-14 |
| NCAAF | 2023/09/30 17:00 | East Tennessee State v Samford | L | 28-42 |
| NCAAF | 2023/09/16 23:00 | East Tennessee State v Austin Peay | L | 3-63 |
| NCAAF | 2023/09/09 21:30 | East Tennessee State v Carson–Newman Eagles | W | 42-0 |
| NCAAF | 2023/09/02 18:00 | East Tennessee State v Jacksonville State | L | 3-49 |
| NCAAF | 2022/11/19 17:00 | East Tennessee State v Mississippi State | L | 7-56 |
| NCAAF | 2022/11/12 18:00 | Western Carolina v East Tennessee State | L | 20-17 |
| NCAAF | 2022/10/29 17:30 | East Tennessee State v Wofford | L | 41-48 |
| NCAAF | 2022/10/22 19:30 | Samford v East Tennessee State | L | 55-45 |