[14] Santos Laguna 1-1 Queretaro [16] 2022-04-17 00:00
Stadium: Estadio TSM Corona Round: 14
Referee: Cesar Arturo Ramos Palazuelos Home Manager: Eduardo Fentanes Away Manager: Hernan Cristante
Head to Head
| Meksyk - Liga MX | 2021/10/30 22:00 | Queretaro v Santos Laguna | W | 2-3 |
| Meksyk - Liga MX | 2021/05/09 02:15 | Santos Laguna v Queretaro | W | 5-0 |
| Meksyk - Liga MX | 2021/04/12 00:00 | Queretaro v Santos Laguna | L | 1-0 |
| Meksyk - Liga MX | 2020/08/31 00:06 | Santos Laguna v Queretaro | W | 2-1 |
| Meksyk - Liga MX | 2019/10/30 01:00 | Santos Laguna v Queretaro | W | 1-0 |
| Meksyk - Liga MX | 2019/04/21 23:06 | Santos Laguna v Queretaro | W | 2-1 |
| Meksyk - Liga MX | 2018/11/04 22:00 | Queretaro v Santos Laguna | L | 2-1 |
| Meksyk - Liga MX | 2018/04/08 23:00 | Santos Laguna v Queretaro | W | 3-0 |
Home History
| Meksyk - Liga MX | 2022/04/10 00:06 | Monterrey v Santos Laguna | L | 1-0 |
| Meksyk - Liga MX | 2022/04/04 00:00 | Santos Laguna v Pachuca | W | 3-1 |
| Meksyk - Liga MX | 2022/03/19 03:00 | Puebla v Santos Laguna | D | 2-2 |
| Meksyk - Liga MX | 2022/03/14 01:00 | Santos Laguna v Tijuana | W | 4-0 |
| Meksyk - Liga MX | 2022/03/06 03:00 | Chivas Guadalajara v Santos Laguna | L | 1-0 |
| Meksyk - Liga MX | 2022/03/03 03:00 | Santos Laguna v Unam Pumas | W | 3-2 |
| Meksyk - Liga MX | 2022/02/28 01:00 | Cruz Azul v Santos Laguna | W | 1-2 |
| Puchar Mistrzów CONCACAF | 2022/02/24 01:15 | CF Montreal v Santos Laguna | L | 3-0 |
Away History
| Meksyk - Liga MX | 2022/04/11 00:00 | Queretaro v Tigres UANL | L | 0-1 |
| Meksyk - Liga MX | 2022/04/03 22:00 | Leon v Queretaro | D | 1-1 |
| Meksyk - Liga MX | 2022/03/18 03:05 | Queretaro v Atletico San Luis | W | 2-1 |
| Meksyk - Liga MX | 2022/03/12 01:00 | Necaxa v Queretaro | L | 1-0 |
| Meksyk - Liga MX | 2022/03/02 03:00 | Club America v Queretaro | D | 1-1 |
| Meksyk - Liga MX | 2022/02/25 03:05 | Queretaro v Toluca | D | 1-1 |
| Meksyk - Liga MX | 2022/02/19 23:00 | Queretaro v Mazatlan FC | W | 2-0 |
| Meksyk - Liga MX | 2022/02/15 03:00 | Pachuca v Queretaro | D | 2-2 |