[13] Santos Laguna 1-4 Necaxa [18] 2022-01-24 01:00
Stadium: Estadio TSM Corona Round: 3
Referee: Victor Alfonso Caceres Hernandez Home Manager: Pedro Caixinha Away Manager: Pablo Guede
Head to Head
| Meksyk - Liga MX | 2021/07/24 00:00 | Necaxa v Santos Laguna | W | 0-3 |
| Meksyk - Liga MX | 2021/03/08 01:06 | Santos Laguna v Necaxa | W | 3-1 |
| Meksyk - Liga MX | 2020/08/22 00:30 | Necaxa v Santos Laguna | L | 2-1 |
| Meksyk - Liga MX | 2020/03/16 00:00 | Santos Laguna v Necaxa | W | 2-1 |
| Meksyk - Liga MX | 2019/08/18 22:00 | Necaxa v Santos Laguna | L | 3-0 |
| Meksyk - Liga MX | 2019/03/18 00:06 | Santos Laguna v Necaxa | L | 1-2 |
| Meksyk - Liga MX | 2018/09/30 02:00 | Necaxa v Santos Laguna | W | 0-1 |
| Puchar Meksyku | 2018/04/05 02:15 | Necaxa v Santos Laguna | L | 2-1 |
Home History
| Meksyk - Liga MX | 2022/01/16 18:00 | Toluca v Santos Laguna | L | 3-1 |
| Meksyk - Liga MX | 2022/01/13 02:06 | Santos Laguna v Tigres UANL | D | 1-1 |
| Meksyk - Liga MX | 2021/11/29 00:00 | Tigres UANL v Santos Laguna | L | 1-0 |
| Meksyk - Liga MX | 2021/11/26 03:05 | Santos Laguna v Tigres UANL | W | 2-1 |
| Meksyk - Liga MX | 2021/11/21 01:00 | Santos Laguna v Atletico San Luis | W | 2-0 |
| Meksyk - Liga MX | 2021/11/08 01:06 | Santos Laguna v Atletico San Luis | D | 0-0 |
| Meksyk - Liga MX | 2021/11/05 01:00 | Unam Pumas v Santos Laguna | W | 0-3 |
| Meksyk - Liga MX | 2021/10/30 22:00 | Queretaro v Santos Laguna | W | 2-3 |
Away History
| Meksyk - Liga MX | 2022/01/15 03:00 | Necaxa v Monterrey | L | 0-4 |
| Meksyk - Liga MX | 2022/01/08 01:00 | Juarez FC v Necaxa | L | 2-1 |
| Europa - Towarzyskie | 2021/12/30 01:00 | Necaxa v Chivas Guadalajara | L | 2-3 |
| Towarzyskie mecze klubowe | 2021/12/23 23:00 | Atletico San Luis v Necaxa | L | 3-1 |
| Meksyk - Liga MX | 2021/11/06 23:00 | Leon v Necaxa | L | 3-0 |
| Meksyk - Liga MX | 2021/10/30 00:00 | Necaxa v Mazatlan FC | W | 2-1 |
| Meksyk - Liga MX | 2021/10/23 22:06 | Monterrey v Necaxa | W | 0-1 |
| Meksyk - Liga MX | 2021/10/21 00:00 | Toluca v Necaxa | D | 1-1 |