Stadium: Meares Stadium Round: 1
| NCAAF | 2021/09/09 23:00 | Mars Hill Lions v Lynchburg Dragons | W | 50-14 |
| NCAAF | 2021/09/02 23:00 | Mars Hill Lions v Chowan Hawks | L | 24-30 |
| NCAAF | 2019/11/16 18:00 | Mars Hill Lions v Wingate Bulldogs | L | 34-64 |
| NCAAF | 2019/11/09 18:30 | Tusculum Pioneers v Mars Hill Lions | L | 24-7 |
| NCAAF | 2019/11/02 17:00 | Mars Hill Lions v Carson–Newman Eagles | L | 21-48 |
| NCAAF | 2019/10/26 17:30 | Catawba Indians v Mars Hill Lions | W | 28-55 |
| NCAAF | 2019/10/19 17:30 | Mars Hill Lions v Limestone Saints | W | 35-28 |
| NCAAF | 2019/10/12 20:00 | Unc Pembroke Braves v Mars Hill Lions | L | 36-29 |
| NCAAF | 2021/09/11 23:30 | East Tennessee State v Virginia Wise Highland Cavaliers | L | 45-14 |
| NCAAF | 2021/09/04 16:00 | Virginia Wise Highland Cavaliers v Lynchburg Dragons | W | 54-0 |
| NCAAF | 2019/11/16 18:00 | Unc Pembroke Braves v Virginia Wise Highland Cavaliers | L | 20-7 |
| NCAAF | 2019/11/09 16:00 | Virginia Wise Highland Cavaliers v Catawba Indians | W | 21-14 |
| NCAAF | 2019/11/02 18:00 | Virginia Wise Highland Cavaliers v Limestone Saints | L | 6-27 |
| NCAAF | 2019/10/26 22:00 | Wingate Bulldogs v Virginia Wise Highland Cavaliers | L | 45-13 |
| NCAAF | 2019/10/19 17:00 | Virginia Wise Highland Cavaliers v Tusculum Pioneers | L | 19-21 |
| NCAAF | 2019/10/12 20:00 | Newberry Wolves v Virginia Wise Highland Cavaliers | L | 30-7 |