[39] John Isner 7-6,3-6,7-6 Andrey Rublev [7] 2021-05-06 13:20
Stadium: Arantxa Sanchez Stadium Round: 26 Ground: Clay
Home History
| ATP Madryt | 2021/05/05 16:00 | Roberto Bautista-Agut v John Isner | 4-6,7-6,6-7 |
| ATP Madryt | 2021/05/03 09:00 | John Isner v Miomir Kecmanovic | 6-4,7-6 |
| ATP Miami | 2021/03/30 15:00 | John Isner v Roberto Bautista-Agut | 3-6,6-4,6-7 |
| ATP Miami | 2021/03/28 15:00 | Felix Auger Aliassime v John Isner | 6-7,6-7 |
| ATP Miami | 2021/03/27 01:05 | Mackenzie McDonald v John Isner | 6-2,3-6,5-7 |
| ATP Acapulco | 2021/03/18 04:00 | Stefanos Tsitsipas v John Isner | 6-3,6-2 |
| ATP Acapulco | 2021/03/16 01:20 | John Isner v Salvatore Caruso | 6-4,6-3 |
| ATP Delray Beach | 2021/01/11 23:00 | Sebastian Korda v John Isner | 6-3,4-6,6-3 |
Away History
| ATP Madryt | 2021/05/04 10:50 | Tommy Paul v Andrey Rublev | 7-6,3-6,4-6 |
| ATP Barcelona | 2021/04/23 10:30 | Jannik Sinner v Andrey Rublev | 6-2,7-6 |
| ATP Barcelona | 2021/04/22 09:00 | Albert Ramos-Vinolas v Andrey Rublev | 4-6,7-6,4-6 |
| ATP Barcelona | 2021/04/21 09:00 | Federico Gaio v Andrey Rublev | 4-6,3-6 |
| ATP Monte Carlo | 2021/04/18 12:30 | Stefanos Tsitsipas v Andrey Rublev | 6-3,6-3 |
| ATP Monte Carlo | 2021/04/17 12:55 | Andrey Rublev v Casper Ruud | 6-3,7-5 |
| ATP Monte Carlo | 2021/04/16 15:30 | Andrey Rublev v Rafael Nadal | 6-2,4-6,6-2 |
| ATP Monte Carlo | 2021/04/15 14:50 | Andrey Rublev v Roberto Bautista-Agut | 7-6,5-7,6-3 |