[13] Queretaro 1-0 Santos Laguna [4] 2021-04-12 00:00
Stadium: Estadio La Corregidora Round: 14
Referee: Fernando Hernandez Gomez Home Manager: Hector Altamirano Escudero Away Manager: Guillermo Almada
Head to Head
| Meksyk - Liga MX | 2020/08/31 00:06 | Santos Laguna v Queretaro | L | 2-1 |
| Meksyk - Liga MX | 2019/10/30 01:00 | Santos Laguna v Queretaro | L | 1-0 |
| Meksyk - Liga MX | 2019/04/21 23:06 | Santos Laguna v Queretaro | L | 2-1 |
| Meksyk - Liga MX | 2018/11/04 22:00 | Queretaro v Santos Laguna | W | 2-1 |
| Meksyk - Liga MX | 2018/04/08 23:00 | Santos Laguna v Queretaro | L | 3-0 |
| Puchar Meksyku | 2018/03/14 03:15 | Santos Laguna v Queretaro | L | 1-0 |
| Meksyk - Liga MX | 2017/10/21 22:00 | Queretaro v Santos Laguna | L | 1-2 |
| Meksyk - Liga MX | 2017/04/02 23:00 | Santos Laguna v Queretaro | L | 1-0 |
Home History
| Meksyk - Liga MX | 2021/04/05 00:00 | Queretaro v Tigres UANL | L | 0-1 |
| Meksyk - Liga MX | 2021/03/21 03:05 | Tijuana v Queretaro | L | 3-1 |
| Meksyk - Liga MX | 2021/03/15 00:00 | Queretaro v Atletico San Luis | W | 2-1 |
| Meksyk - Liga MX | 2021/03/07 01:06 | Monterrey v Queretaro | L | 2-1 |
| Meksyk - Liga MX | 2021/03/04 01:00 | Queretaro v Chivas Guadalajara | D | 2-2 |
| Meksyk - Liga MX | 2021/02/27 03:30 | Mazatlan FC v Queretaro | L | 3-0 |
| Meksyk - Liga MX | 2021/02/21 23:00 | Queretaro v Puebla | D | 1-1 |
| Meksyk - Liga MX | 2021/02/14 03:00 | Club America v Queretaro | L | 2-1 |
Away History
| Meksyk - Liga MX | 2021/04/04 22:00 | Chivas Guadalajara v Santos Laguna | D | 1-1 |
| Meksyk - Liga MX | 2021/03/22 01:06 | Santos Laguna v Leon | L | 1-2 |
| Meksyk - Liga MX | 2021/03/14 03:05 | Tijuana v Santos Laguna | W | 0-1 |
| Meksyk - Liga MX | 2021/03/08 01:06 | Santos Laguna v Necaxa | W | 3-1 |
| Meksyk - Liga MX | 2021/03/05 03:00 | Unam Pumas v Santos Laguna | L | 1-0 |
| Meksyk - Liga MX | 2021/03/01 01:06 | Santos Laguna v Juarez FC | W | 3-2 |
| Meksyk - Liga MX | 2021/02/19 03:00 | Atletico San Luis v Santos Laguna | L | 1-0 |
| Meksyk - Liga MX | 2021/02/15 01:06 | Santos Laguna v Monterrey | W | 1-0 |